Faecal Metabolomics in Paediatric Inflammatory Bowel Disease: A Systematic Review.

ABSTRACT:

Background and aims

Paediatric inflammatory bowel disease [IBD] is characterized by altered immunological and metabolic pathways. Metabolomics may therefore increase pathophysiological understanding and could develop into characterization of biomarkers for diagnosis and IBD treatment response. However, no uniform metabolomic profiles have been identified to date. This systematic review aimed to identify faecal metabolomic signatures in paediatric IBD vs controls, and to describe metabolites associated with disease activity and treatment response.

Methods

A literature search was performed in Embase, Medline, Web of Science and Cochrane Library. Studies assessing faecal metabolomics in paediatric patients < 18 years with IBD [de novo, active, inactive] with comparative groups

SUBMITTER: Jagt JZ 

PROVIDER: S-EPMC9683079 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature