Hemodynamic indicators of the formation of tandem intracranial aneurysm based on a vascular restoration algorithm.

ABSTRACT:

Background

Hemodynamic factors are believed to be closely related to IA growth. However, the underlying pathophysiological mechanism that induces the growth sequence in tandem intracranial aneurysms (IAs) remains unclear.

Methods and results

This study involved five patients with tandem IAs. Aneurysm models were reconstructed based on image datasets. A novel vascular restoration algorithm was proposed to generate the hypothetical geometry of the healthy parent vessel before each IA formation in the concatenated structure. Detailed hemodynamic patterns and morphological features were revealed under various growth sequences of tandem IAs to investigate the flow-driven mechanism of IA growth. Potential hemodynamic indicators of IA formation were proposed.

Results

The pat

SUBMITTER: Yao Y 

PROVIDER: S-EPMC9683096 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature