Exogenous glycogen utilization effects the transcriptome and pathogenicity of Streptococcus suis serotype 2.

ABSTRACT: Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen that causes severe infections in humans and the swine industry. Acquisition and utilization of available carbon sources from challenging host environments is necessary for bacterial pathogens to ensure growth and proliferation. Glycogen is abundant in mammalian body and may support the growth of SS2 during infection in hosts. However, limited information is known about the mechanism between the glycogen utilization and host adaptation of SS2. Here, the pleiotropic effects of exogenous glycogen on SS2 were investigated through transcriptome sequencing. Analysis of transcriptome data showed that the main basic metabolic pathways, especially the core carbon metabolism pathways and virulence-associated factors, of SS2

SUBMITTER: Tan MF 

PROVIDER: S-EPMC9683343 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature