Development of a Highly Responsive Organofluorine Temperature Sensor for ¹⁹F Magnetic Resonance Applications.

ABSTRACT: Temperature can affect many biological and chemical processes within a body. During in vivo measurements, varied temperature can impact the accurate quantification of additional abiotic factors such as oxygen. During magnetic resonance imaging (MRI) measurements, the temperature of the sample can increase with the absorption of radiofrequency energy, which needs to be well-regulated for thermal therapies and long exposure. To address this potentially confounding effect, temperature can be probed intentionally using reporter molecules to determine the temperature in vivo. This work describes a combined experimental and computational approach for the design of fluorinated molecular temperature sensors with the potential to improve the accuracy and sensitivity of ¹⁹F

SUBMITTER: Lee AL 

PROVIDER: S-EPMC9683353 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature