CD4 and IL-2 mediated NK cell responses after COVID-19 infection and mRNA vaccination in adults.

ABSTRACT: A detailed understanding of protective immunity against SARS-CoV-2 is incredibly important in fighting the pandemic. Central to protective immunity is the ability of the immune system to recall previous exposures. Although antibody and T cell immunity have gained considerable attention, the contribution of the NK cell compartment to immune recall and protection from SARS-CoV-2 has not been explored. In this study, we investigate the NK cell responses to stimulation with SARS-CoV-2 in previously exposed and non-exposed individuals. We show that NK cells demonstrate an enhanced CD4+ T cell dependent response when re-exposed to SARS-CoV-2 antigen. The enhanced response is dependent on T cells and correlates with the number of SARS-CoV-2 specific CD4 T cells. We find that IL-2 is a critical me

SUBMITTER: Alhajjat AM 

PROVIDER: S-EPMC9683520 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature