Race, Interleukin-6, <i>TMPRSS6</i> Genotype, and Cardiovascular Disease in Patients With Chronic Kidney Disease.

ABSTRACT: Background Differences in death rate and cardiovascular disease (CVD) between Black and White patients with chronic kidney disease is attributed to sociocultural factors, comorbidities, genetics, and inflammation. Methods and Results We examined the interaction of race, plasma IL-6 (interleukin-6), and TMPRSS6 genotype as determinants of CVD and mortality in 3031 Chronic Renal Insufficiency Cohort study participants. The primary outcomes were all-cause mortality and a composite of incident myocardial infarction, peripheral artery disease, stroke, and heart failure. During the median follow-up of 10 years, Black patients with chronic kidney disease experienced a significantly higher mortality (34% versus 26%) and CVD composite (41% versus 28%) compared with White patients. After adju

SUBMITTER: Barrows IR 

PROVIDER: S-EPMC9683639 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature