Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition.

ABSTRACT: Neuronal connectivity and activity-dependent synaptic plasticity are fundamental properties that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) intracellular signaling controls multiple mechanisms mediating neuronal growth, synaptic structure, and plasticity. However, it is still unclear how these pleiotropic functions are integrated at molecular and cellular levels. To address this issue, we used neuron-specific virally delivered Cre expression to delete either p110α or p110β (the two major catalytic isoforms of type I PI3K) from the hippocampus of adult mice. We found that dendritic and postsynaptic structures are almost exclusively supported by p110α activity, whereas p110β controls neurotransmitter release and metabotropic glutamate receptor-depe

SUBMITTER: Sanchez-Castillo C 

PROVIDER: S-EPMC9683729 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature