Landscape of epithelial-mesenchymal plasticity as an emergent property of coordinated teams in regulatory networks.

ABSTRACT: Elucidating the design principles of regulatory networks driving cellular decision-making has fundamental implications in mapping and eventually controlling cell-fate decisions. Despite being complex, these regulatory networks often only give rise to a few phenotypes. Previously, we identified two 'teams' of nodes in a small cell lung cancer regulatory network that constrained the phenotypic repertoire and aligned strongly with the dominant phenotypes obtained from network simulations (Chauhan et al., 2021). However, it remained elusive whether these 'teams' exist in other networks, and how do they shape the phenotypic landscape. Here, we demonstrate that five different networks of varying sizes governing epithelial-mesenchymal plasticity comprised of two 'teams' of players - one comprised

SUBMITTER: Hari K 

PROVIDER: S-EPMC9683792 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature