Dissecting Regulators of Aging and Age-Related Macular Degeneration in the Retinal Pigment Epithelium.

ABSTRACT: Age-related macular degeneration (AMD), the leading cause of blindness in elderly populations, involves the loss of central vision due to progressive dysfunction of the retinal pigment epithelium (RPE) and subsequent loss of light-sensing photoreceptors. While age is a key risk factor, not every aged individual develops AMD. Thus, the critical question is what specific cellular changes tip the balance from healthy aging to disease. To distinguish between changes associated with aging and AMD, we compared the RPE proteome in human eye bank tissue from nondiseased donors during aging (n = 50, 29-91 years) and in donors with AMD (n = 36) compared to age-matched donors without disease (n = 28). Proteins from RPE cells were separated on two-dimensional gels, analyzed for co

SUBMITTER: Karunadharma PP 

PROVIDER: S-EPMC9683958 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature