Dataset Information

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach.

ABSTRACT:

Background

Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown.

Purpose

This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo.

Methods

An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome and metabolome of XRG-4.

Result

A total of 106 constituents were identified in XRG-4. Eighty-nine components were identified in biological samples, including 78 in urine (24 prototypes and 54 metabolites), 26 in feces (19 prototypes and 7 metabolites), and 9 in plasma (5 prototypes and 4 metabolites). In other tissues, only a few compounds, including alkaloids and iridoids, were detected.

Conclusion

This comprehensive investigation of the chemical and metabolic profiles of XRG-4 provides a scientific foundation for its quality control and administration of clinically-safe medication.

SUBMITTER: Ma Y

PROVIDER: S-EPMC9683986 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach.

Ma Yuanyuan Y Ma Ruiting R ZhiGui Sa QiLa Q Zhao Na N Wurigumala Burentegusi Guo Zhigang Z Tumenwuliji

Evidence-based complementary and alternative medicine : eCAM 20221116

<h4>Background</h4>Xieriga-4 decoction (XRG-4) is a classic prescription Mongolian medicine that has potent diuretic and anti-inflammatory activities. However, its functional components remain unknown.<h4>Purpose</h4>This study aimed to identify the chemical components in XRG-4 and its metabolome in vivo.<h4>Methods</h4>An ultra-performance liquid chromatography coupled with a quadrupole time-of-flight tandem mass spectrometry based approach was proposed to systematically profile the chemicolome ...[more]

PMID: 36437832

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Dataset Information

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach.

Background

Purpose

Methods

Result

Conclusion

Publications

Chemicolome and Metabolome Profiling of Xieriga-4 Decoction, A Traditional Mongolian Medicine, Using the UPLC-QTOF/MS Approach.

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