Vibrio cholerae-Symbiont Interactions Inhibit Intestinal Repair in Drosophila.

ABSTRACT: Pathogen-mediated damage to the intestinal epithelium activates compensatory growth and differentiation repair programs in progenitor cells. Accelerated progenitor growth replenishes damaged tissue and maintains barrier integrity. Despite the importance of epithelial renewal to intestinal homeostasis, we know little about the effects of pathogen-commensal interactions on progenitor growth. We find that the enteric pathogen Vibrio cholerae blocks critical growth and differentiation pathways in Drosophila progenitors, despite extensive damage to epithelial tissue. We show that the inhibition of epithelial repair requires interactions between the Vibrio cholerae type six secretion system and a community of common symbiotic bacteria, as elimination of the gut microbiome is sufficient to restor

SUBMITTER: Fast D 

PROVIDER: S-EPMC9684019 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature