Dataset Information

Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study).

ABSTRACT:

Background

The risk of barotrauma associated with different types of ventilatory support is unclear in COVID-19 patients. The primary aim of this study was to evaluate the effect of the different respiratory support strategies on barotrauma occurrence; we also sought to determine the frequency of barotrauma and the clinical characteristics of the patients who experienced this complication.

Methods

This multicentre retrospective case-control study from 1 March 2020 to 28 February 2021 included COVID-19 patients who experienced barotrauma during hospital stay. They were matched with controls in a 1:1 ratio for the same admission period in the same ward of treatment. Univariable and multivariable logistic regression (OR) were performed to explore which factors were associated with barotrauma and in-hospital death.

Results

We included 200 cases and 200 controls. Invasive mechanical ventilation was used in 39.3% of patients in the barotrauma group, and in 20.1% of controls (p<0.001). Receiving non-invasive ventilation (C-PAP/PSV) instead of conventional oxygen therapy (COT) increased the risk of barotrauma (OR 5.04, 95% CI 2.30 - 11.08, p<0.001), similarly for invasive mechanical ventilation (OR 6.24, 95% CI 2.86-13.60, p<0.001). High Flow Nasal Oxygen (HFNO), compared with COT, did not significantly increase the risk of barotrauma. Barotrauma frequency occurred in 1.00% [95% CI 0.88-1.16] of patients; these were older (p=0.022) and more frequently immunosuppressed (p=0.013). Barotrauma was shown to be an independent risk for death (OR 5.32, 95% CI 2.82-10.03, p<0.001).

Conclusions

C-PAP/PSV compared with COT or HFNO increased the risk of barotrauma; otherwise HFNO did not. Barotrauma was recorded in 1.00% of patients, affecting mainly patients with more severe COVID-19 disease. Barotrauma was independently associated with mortality.

Trial registration

this case-control study was prospectively registered in clinicaltrial.gov as NCT04897152 (on 21 May 2021).

SUBMITTER: Vetrugno L

PROVIDER: S-EPMC9684110 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study).

Vetrugno Luigi L Castaldo Nadia N Fantin Alberto A Deana Cristian C Cortegiani Andrea A Longhini Federico F Forfori Francesco F Cammarota Gianmaria G Grieco Domenico Luca DL Isola Miriam M Navalesi Paolo P Maggiore Salvatore Maurizio SM Bassetti Matteo M Chetta Alfredo A Confalonieri Marco M De Martino Maria M Ferrari Giovanni G Francisi Daniela D Luzzati Roberto R Meini Simone S Scozzafava Mariano M Sozio Emanuela E Tascini Carlo C Bassi Flavio F Patruno Vincenzo V De Robertis Edoardo E Aldieri Chiara C Ball Lorenzo L Baratella Elisa E Bartoletti Michele M Boscolo Annalisa A Burgazzi Barbara B Catalanotti Vito V Confalonieri Paola P Corcione Silvia S De Rosa Francesco Giuseppe FG De Simoni Alessandro A Bono Valerio Del VD Tria Roberta Di RD Forlani Sara S Giacobbe Daniele Roberto DR Granozzi Bianca B Labate Laura L Lococo Sara S Lupia Tommaso T Matellon Carola C Mehrabi Sara S Morosi Sabrina S Mongodi Silvia S Mura Maddalena M Nava Stefano S Pol Riccardo R Pettenuzzo Tommaso T Quyen Nguyen Hoang NH Rescigno Carolina C Righi Elda E Ruaro Barbara B Salton Francesco F Scabini Silvia S Scarda Angelo A Sibani Marcella M Tacconelli Evelina E Tartaglione Gennaro G Tazza Beatrice B Vania Eleonora E Viale Pierluigi P Vianello Andrea A Visentin Alessandro A Zuccon Umberto U Meroi Francesco F Buonsenso Danilo D

Pulmonology 20221124 6

<h4>Background</h4>The risk of barotrauma associated with different types of ventilatory support is unclear in COVID-19 patients. The primary aim of this study was to evaluate the effect of the different respiratory support strategies on barotrauma occurrence; we also sought to determine the frequency of barotrauma and the clinical characteristics of the patients who experienced this complication.<h4>Methods</h4>This multicentre retrospective case-control study from 1 March 2020 to 28 February 2 ...[more]

PMID: 36669936

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Dataset Information

Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study).

Background

Methods

Results

Conclusions

Trial registration

Publications

Ventilatory associated barotrauma in COVID-19 patients: A multicenter observational case control study (COVI-MIX-study).

Similar Datasets

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