Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging.

ABSTRACT: Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological and psychiatric disorders. Magnetic resonance (MR) and optoacoustic (OA) imaging have been shown to provide highly complementary contrasts and capabilities for preclinical neuroimaging. True integration between these modalities can thus offer unprecedented capabilities for studying the rodent brain in action. We report on a hybrid magnetic resonance and optoacoustic tomography (MROT) system for concurrent noninvasive structural and functional imaging of the mouse brain. Volumetric OA tomography was designed as an insert into a high-field MR scanner by integrating a customized MR-compatible spherical transducer array, an illumination module,

SUBMITTER: Chen Z 

PROVIDER: S-EPMC9684112 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature