Disrupted gut microbiota aggravates working memory dysfunction induced by high-altitude exposure in mice.

ABSTRACT:

Background

The widely accepted microbiome-gut-brain axis (MGBA) hypothesis may be essential for explaining the impact of high-altitude exposure on the human body, especially brain function. However, studies on this topic are limited, and the underlying mechanism remains unclear. Therefore, this study aimed to determine whether high-altitude-induced working memory dysfunction could be exacerbated with gut microbiota disruption.

Methods and results

C57BL/6 mice were randomly divided into three groups: control, high-altitude exposed (HAE), and high-altitude exposed with antibiotic treatment (HAE-A). The HAE and HAE-A groups were exposed to a low-pressure oxygen chamber (60-65 kPa) simulating the altitude of 3,500-4,000 m for 14 days, The air pressure level for the control group

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC9684180 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature