Clinical and cortical similarities identified between bipolar disorder I and schizophrenia: A multivariate approach.

ABSTRACT:

Background

Structural neuroimaging studies have identified similarities in the brains of individuals diagnosed with schizophrenia (SZ) and bipolar I disorder (BP), with overlap in regions of gray matter (GM) deficits between the two disorders. Recent studies have also shown that the symptom phenotypes associated with SZ and BP may allow for a more precise categorization than the current diagnostic criteria. In this study, we sought to identify GM alterations that were unique to each disorder and whether those alterations were also related to unique symptom profiles.

Materials and methods

We analyzed the GM patterns and clinical symptom presentations using independent component analysis (ICA), hierarchical clustering, and n-way biclustering in a large (N ∼ 3,000), merg

SUBMITTER: Rootes-Murdy K 

PROVIDER: S-EPMC9684186 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature