Panoramic Insights into Microevolution and Macroevolution of A Prevotella copri-containing Lineage in Primate Guts.

ABSTRACT: Prevotella copri and its related taxa are widely detected in mammalian gut microbiomes and have been linked with an enterotype in humans. However, their microevolution and macroevolution among hosts are poorly characterized. In this study, extensively collected marker genes and genomes were analyzed to trace their evolutionary history, host specificity, and biogeographic distribution. Investigations based on marker genes and genomes suggest that a P. copri-containing lineage (PCL) harbors diverse species in higher primates. Firstly, P. copri in the human gut consisted of multiple groups exhibiting high genomic divergence and conspicuous but non-strict biogeographic patterns. Most African strains with high genomic divergence from other strains were phylogenetically located at the root of th

SUBMITTER: Li H 

PROVIDER: S-EPMC9684210 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature