CD11c regulates late-stage T cell development in the thymus.

ABSTRACT: CD11c, also named integrin αX, has been deemed solely as a dendritic cell marker for decades while the delineation of its biological function was limited. In the current study, we observed in mice that CD11c deficiency led to a defect in T cell development, demonstrated by the loss of CD4⁺CD8⁺ double positive (DP) T cells, CD4⁺CD8^-, and CD4^-CD8⁺ single positive (SP) T cells in the thymus and less mature T cells in the periphery. By using bone marrow chimera, we confirmed that CD11c regulated T cell development in the thymus. We further showed that CD11c deficiency led to an accelerated apoptosis of CD3 positive thymocytes, but not CD4^-CD8^- double negative (DN) T cells. Overall, this study added one more

SUBMITTER: Hou L 

PROVIDER: S-EPMC9684328 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature