Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease.

ABSTRACT:

Introduction

As knowledge about neurological examination findings in autosomal dominant Alzheimer disease (ADAD) is incomplete, we aimed to determine the frequency and significance of neurological examination findings in ADAD.

Methods

Frequencies of neurological examination findings were compared between symptomatic mutation carriers and non mutation carriers from the Dominantly Inherited Alzheimer Network (DIAN) to define AD neurological examination findings. AD neurological examination findings were analyzed regarding frequency, association with and predictive value regarding cognitive decline, and association with brain atrophy in symptomatic mutation carriers.

Results

AD neurological examination findings included abnormal deep tendon reflexes, gait disturbance, pa

SUBMITTER: Voglein J 

PROVIDER: S-EPMC9684350 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature