Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP.
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ABSTRACT:
SUBMITTER: McFall T
PROVIDER: S-EPMC9684405 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
Co-targeting KRAS G12C and EGFR reduces both mutant and wild-type RAS-GTP.
McFall Thomas T Trogdon Michael M Guizar Anita C AC Langenheim John F JF Sisk-Hackworth Laura L Stites Edward C EC
NPJ precision oncology 20221123 1
The combination of KRAS G12C inhibitors with EGFR inhibitors has reproducibly been shown to be beneficial. Here, we identify another benefit of this combination: it effectively inhibits both wild-type and mutant RAS. We believe that targeting both mutant and wild-type RAS helps explain why this combination of inhibitors is effective. ...[more]
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