Oocyte phenotype, genetic diagnosis, and clinical outcome in case of patients with oocyte maturation arrest.

ABSTRACT:

Background

oocyte maturation arrest (OMA) is currently one of the major causes of in vitro fertilization (IVF) failure, and several gene mutations were found to be associated with OMA. The purpose of this study was to identify the oocyte phenotype, genetic diagnosis, and clinical outcomes of patients with OMA and explore their possible interrelationships, thus providing a more individualized and efficient treatment strategy guidance accordingly.

Methods

A retrospective study was conducted, involving 28 infertile women with OMA in the Reproductive Medicine Center of Tongji Hospital from 2018 to 2021. Whole-exome sequencing was performed for the detection of gene mutations. Patients were classified into three groups based on their oocyte phenotype, and for each group, t

SUBMITTER: Zhu L 

PROVIDER: S-EPMC9684610 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature