Shotgun metagenomic sequencing analysis of ocular surface microbiome in Singapore residents with mild dry eye.

ABSTRACT: The ocular surface microbiome has implications for ocular surface inflammation and immunology. Previous shotgun metagenomics analyses were performed in China, showing results that differed according to environment and age. Patients with Sjogren's syndrome were reported to have altered conjunctival microbiome, but such studies have not been done in milder dry eye. The aim of this study is to describe the conjunctival microbiome in people with mild dry eye in Singapore. Samples were collected from 14 participants with mild dry eye and 10 age-matched comparison participants recruited from Singapore National Eye Centre (SNEC) clinics. Shotgun metagenomic sequencing analysis was employed to evaluate the conjunctival microbiome composition. Proteobacteria formed the predominant phylum in

SUBMITTER: Tong L 

PROVIDER: S-EPMC9684611 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature