The concentration of lidocaine and mepivacaine measured in synovial fluid of different joints of horses after single intra-articular injection.

ABSTRACT:

Objective

To determine the synovial fluid (SF) concentrations of lidocaine and mepivacaine after intra-articular injection with clinically relevant doses to the distal interphalangeal (DIP), metacarpophalangeal (MCP), middle carpal (MC), and tarsocrural (TC) joint at two different time points after injection in order to be able to compare concentrations with previously established concentrations associated with cytotoxicity and antimicrobial activity.

Procedures

In the first of two experiments, 20 joints (5 MC, 5 MCP, 10 DIP joints) of five horses under general anesthesia were injected with clinically referenced doses of 2% lidocaine. Simultaneously, the horses had 19 joints (5 MC, 5 MCP, 9 DIP joints) injected with clinically referenced doses of 2% mepivacaine. Synovial flu

SUBMITTER: Adler DMT 

PROVIDER: S-EPMC9684627 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature