SKA1/2/3 is a biomarker of poor prognosis in human hepatocellular carcinoma.

ABSTRACT:

Background

Spindle and kinetochore-associated complex subunits 1-3 (SKA1-3) stabilize the kinetochore-attached spindle microtubules in metaphase. Due to the dysregulation in multiple cancers, SKA1-3 is considered a predictor for the prognosis of the patients. However, the potential clinical applications of SKA1-3, particularly in hepatocellular carcinoma (HCC) prognosis and progression, have completely unknown yet.

Methods

For the analysis of SKA1-3 expression and applications in clinics in HCC patients, several databases, such as STRING, UALCAN, GEO, and TCGA, were searched. In addition, the underlying mechanisms of SKA for the regulation of HCC occurrence, development, and progression were also explored.

Results

Compared to the normal controls, HCC patients showed d

SUBMITTER: Song GQ 

PROVIDER: S-EPMC9684634 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature