Derivation and external validation of a simple prediction rule for the development of respiratory failure in hospitalized patients with influenza.

ABSTRACT:

Background

Influenza viruses cause seasonal epidemics worldwide with a significant morbimortality burden. Clinical spectrum of Influenza is wide, being respiratory failure (RF) one of its most severe complications. This study aims to elaborate a clinical prediction rule of RF in hospitalized Influenza patients.

Methods

A prospective cohort study was conducted during two consecutive Influenza seasons (December 2016-March 2017 and December 2017-April 2018) including hospitalized adults with confirmed A or B Influenza infection. A prediction rule was derived using logistic regression and recursive partitioning, followed by internal cross-validation. External validation was performed on a retrospective cohort in a different hospital between December 2018 and May 2019.

Results

SUBMITTER: Ayuso B 

PROVIDER: S-EPMC9684757 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature