Higher body mass index is associated with a lower iloprost infusion rate tolerance and higher iloprost-related adverse events in patients with systemic sclerosis.

ABSTRACT:

Background

Systemic sclerosis (SSc) is an autoimmune disease characterized by vasospasm and microvascular involvement. Iloprost (ILO), a prostaglandin analogous, is used for the treatment of SSc-related Raynaud's phenomenon and digital ulcers. The suggested dose is 0.5-2 ng/kg/min for 6-8 h, and the maximum dose is decided upon the patient's tolerance.

Objectives

This study aims to analyze ILO infusion tolerance and possible predictive factors in patients with SSc.

Design

This is a retrospective observational study.

Method

We evaluated 113 patients with SSc beginning ILO intravenous (IV) infusion treatment between 2004 and 2021. We assessed the maximum tolerated ILO IV infusion rate, the incidence of adverse events (AEs), and the need for symptomatic therapy du

SUBMITTER: Bixio R 

PROVIDER: S-EPMC9685102 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature