Purine metabolism-related gene expression signature predicts survival outcome and indicates immune microenvironment profile of gliomas.

ABSTRACT: Glioma is the most common malignant tumor in the central nervous system. The impact of metabolism on cancer development and the immune microenvironment landscape has recently gained broad attention. Purines are involved in multiple metabolic pathways. It has been proved that purine metabolism could regulate malignant biological behaviors and response to immune checkpoint inhibitors in multiple cancers. However, the relationship of purine metabolism with clinicopathological features and the immune landscape of glioma remains unclear. In this study, we explored the relationships between the expression of purine metabolism-related genes (PuMGs) and tumor features, including prognosis and microenvironment of glioma, based on analyses of 1,523 tumors from 4 public databases and our cohort. Cons

SUBMITTER: Chen S 

PROVIDER: S-EPMC9685320 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature