MSCs can be a double-edged sword in tumorigenesis.
Ontology highlight
ABSTRACT:
SUBMITTER: Zhang L
PROVIDER: S-EPMC9685321 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Publications
MSCs can be a double-edged sword in tumorigenesis.
Zhang Lu L Xiang Junyu J Zhang Fang F Liu Limei L Hu Chongling C
Frontiers in oncology 20221110
Mesenchymal stem cells (MSCs) have been used to treat various diseases including Alzheimer's disease and cancer. In particular, the immunomodulatory function of MSCs plays a major role in cancer therapy using stem cells. However, MSCs exert promotive and inhibitory effects on cancer. The immunomodulatory effects of MSCs in the tumor microenvironment (TME) are ambiguous, which is the primary reason for the different outcomes of MSCs therapies for tumors. This review discusses the use of MSCs in c ...[more]
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