SIRT1 activation attenuates microglia-mediated synaptic engulfment in postoperative cognitive dysfunction.

ABSTRACT:

Background

Postoperative cognitive dysfunction (POCD) is a debilitating neurological complication in surgical patients. Current research has focused mainly on microglial activation, but less is known about the resultant neuronal synaptic changes. Recent studies have suggested that Sirtuin-1 (SIRT1) plays a critical role in several different neurological disorders via its involvement in microglial activation. In this study, we evaluate the effects of SIRT1 activation in a POCD mouse model.

Materials and methods

Exploratory laparotomy was performed in mice aged 12-14 months under sevoflurane anesthesia to establish our animal POCD model. Transcriptional changes in the hippocampus after anesthesia and surgery were evaluated by RNA sequencing. SIRT1 expression was verifie

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9685341 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature