Identification and expression analysis of zebrafish gnaq in the hypothalamic-Pituitary-Gonadal axis.

ABSTRACT: The G proteins have emerged as essential molecular switches in a wide variety of signal transduction pathways. Gαq, encoded by G protein subunit alpha q (gnaq), is a member of the G proteins and participates in regulating important biological activities in mammals; however, its function and regulatory mechanism in teleost remain largely unclear. In the current study, we cloned the cDNA of gnaq from zebrafish (Danio rerio) and investigated the expression characteristics of Gαq/gnaq in reproductive tissues. RT-PCR and WISH analyses showed that gnaq was widely expressed in zebrafish tissues, with high expression in the brain, olfactory brain, and hypothalamus. During the embryonic development stage, the gnaq was mainly distributed in the hypoth

SUBMITTER: Wang C 

PROVIDER: S-EPMC9685404 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature