Analysis of Antibiotic Exposure and Early-Onset Neonatal Sepsis in Europe, North America, and Australia.

ABSTRACT:

Importance

Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS), but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse outcomes. Large international studies quantifying early-life antibiotic exposure along with EOS incidence are needed to provide a basis for future interventions aimed at safely reducing neonatal antibiotic exposure.

Objective

To compare early postnatal exposure to antibiotics, incidence of EOS, and mortality among different networks in high-income countries.

Design, setting, and participants

This is a retrospective, cross-sectional study of late-preterm and full-term neonates born between January 1, 2014, and December 31, 2018, in 13 hospital-based or population-based networks from 1

SUBMITTER: Giannoni E 

PROVIDER: S-EPMC9685486 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature