Molecular Typing and Clinical Characteristics of Synchronous Multiple Primary Colorectal Cancer.

ABSTRACT:

Importance

Synchronous multiple primary colorectal cancer (sMPCC) is clinically rare, but its incidence has increased over the past decade. However, little is known about the molecular and clinical features of sMPCC, which may differ from those of single primary colorectal cancer (SPCRC).

Objective

To evaluate the clinical characteristics and pathogenic variations in lesions and the molecular typing of sMPCC.

Design, setting, and participants

From November 2012 to April 2021, patients with colorectal cancer (CRC) treated at the Sixth Affiliated Hospital of Sun Yat-sen University were enrolled in this cohort study. Follow-up ended on January 31, 2022.

Main outcomes and measures

The primary outcome was mismatch repair (MMR) status of each lesion in all patients e

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC9685491 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature