A genetic association study reveals the relationship between the oral microbiome and anxiety and depression symptoms.

ABSTRACT:

Background

Growing evidence supports that alterations in the gut microbiota play an essential role in the etiology of anxiety, depression, and other psychiatric disorders. However, the potential effect of oral microbiota on mental health has received little attention.

Methods

Using the latest genome-wide association study (GWAS) summary data of the oral microbiome, polygenic risk scores (PRSs) of 285 salivary microbiomes and 309 tongue dorsum microbiomes were conducted. Logistic and linear regression models were applied to evaluate the relationship between salivary-tongue dorsum microbiome interactions with anxiety and depression. Two-sample Mendelian randomization (MR) was utilized to compute the causal effects between the oral microbiome, anxiety, and depression.

Result

SUBMITTER: Li C 

PROVIDER: S-EPMC9685528 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature