A pyroptosis expression pattern score predicts prognosis and immune microenvironment of lung squamous cell carcinoma.

ABSTRACT: Pyroptosis has been proved to significantly influence the development of lung squamous cell carcinoma (LUSC). To better predict overall survival (OS) and provide guidance on the selection of therapy for LUSC patients, we constructed a novel prognostic biomarker based on pyroptosis-related genes. The dataset for model construction were obtained from The Cancer Genome Atlas and the validation dataset were obtained from Gene Expression Omnibus. Differential expression genes between different pyroptosis expression patterns were identified. These genes were then used to construct pyroptosis expression pattern score (PEPScore) through weighted gene co-expression network analysis, univariate and multivariate cox regression analysis. Afterward, the differences in molecule and immune characteristic

SUBMITTER: Chen W 

PROVIDER: S-EPMC9685532 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature