Association of liver disease with brain volume loss, cognitive decline, and plasma neurodegenerative disease biomarkers.

ABSTRACT: Although liver dysfunction has been implicated in Alzheimer's disease (AD), it remains unknown how liver disease may influence the trajectory of brain and cognitive changes in older adults. We related self-reported liver disease to longitudinal measures of brain structure and cognition, as well as baseline measures of plasma AD/neurodegeneration biomarkers in the Baltimore Longitudinal Study of Aging. Liver disease was identified using ICD-9 classification codes. Brain volume and cognition were assessed serially using 3T-MRI and a cognitive battery. 1008, 2157, and 780 participants were included in the MRI, cognitive, and plasma biomarker analysis, respectively. After adjustment for confounders, liver disease was associated with accelerated decline in total brain and white matter volume, b

SUBMITTER: Peng Z 

PROVIDER: S-EPMC9685609 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature