Identification and exploration of novel M2 macrophage-related biomarkers in the development of acute myocardial infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI), one of the most severe and fatal cardiovascular diseases, is a major cause of morbidity and mortality worldwide. Macrophages play a critical role in ventricular remodeling after AMI. The regulatory mechanisms of the AMI progression remain unclear. This study aimed to identify hub regulators of macrophage-related modules and provide translational experiments with potential therapeutic targets.

Materials and methods

The GSE59867 dataset was downloaded from the Gene Expression Omnibus (GEO) database for bioinformatics analysis. The expression patterns of 22 types of immune cells were determined using CIBERSORT. GEO2R was used to identify differentially expressed genes (DEGs) through the limma package. Then, DEGs were clustered into

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9685672 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature