Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.

ABSTRACT:

Introduction

Chronic lung disease, that is, bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and develops as a consequence of the misguided formation of the gas-exchange area undergoing prenatal and postnatal injury. Subsequent vascular disease and its progression into pulmonary arterial hypertension critically determines long-term outcome in the BPD infant but lacks identification of early, disease-defining changes.

Methods

We link impaired bone morphogenetic protein (BMP) signalling to the earliest onset of vascular pathology in the human preterm lung and delineate the specific effects of the most prevalent prenatal and postnatal clinical risk factors for lung injury mimicking clinically relevant conditions in a multilayered animal model

SUBMITTER: Heydarian M 

PROVIDER: S-EPMC9685723 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature