Illuminating links between cis-regulators and trans-acting variants in the human prefrontal cortex.

ABSTRACT:

Background

Neuropsychiatric disorders afflict a large portion of the global population and constitute a significant source of disability worldwide. Although Genome-wide Association Studies (GWAS) have identified many disorder-associated variants, the underlying regulatory mechanisms linking them to disorders remain elusive, especially those involving distant genomic elements. Expression quantitative trait loci (eQTLs) constitute a powerful means of providing this missing link. However, most eQTL studies in human brains have focused exclusively on cis-eQTLs, which link variants to nearby genes (i.e., those within 1 Mb of a variant). A complete understanding of disease etiology requires a clearer understanding of trans-regulatory mechanisms, which, in turn, entails a detailed analysi

SUBMITTER: Liu S 

PROVIDER: S-EPMC9685876 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature