A modular and self-adjuvanted multivalent vaccine platform based on porcine circovirus virus-like nanoparticles.

ABSTRACT:

Background

Virus-like particles (VLPs) are supramolecular structures composed of multiple protein subunits and resemble natural virus particles in structure and size, making them highly immunogenic materials for the development of next-generation subunit vaccines. The orderly and repetitive display of antigenic epitopes on particle surface allows efficient recognition and cross-link by B cell receptors (BCRs), thereby inducing higher levels of neutralizing antibodies and cellular immune responses than regular subunit vaccines. Here, we present a novel multiple antigen delivery system using SpyCatcher/Spytag strategy and self-assembled VLPs formed by porcine circovirus type 2 (PCV2) Cap, a widely used swine vaccine in solo.

Results

Cap-SC, recombinant Cap with a truncated Spy

SUBMITTER: Liu ZH 

PROVIDER: S-EPMC9685936 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature