The effect of SNPs in lncRNA as ceRNA on the risk and prognosis of hepatocellular carcinoma.

ABSTRACT:

Background

Most susceptible loci of hepatocellular carcinoma (HCC) identified by genome-wide association studies (GWAS) are located in non-coding regions, and the mechanism of action remains unclear. The objective of this study was to explore the association of single nucleotide polymorphisms (SNPs) on long non-coding RNAs (lncRNAs) that affect competing endogenous RNAs (ceRNA) regulation mechanism with the risk and prognosis of HCC.

Methods

Based on a set of bioinformatics strategies, eight lncRNA genes that affect HCC through the mechanism of lncRNA-mediated ceRNA were systematically screened, and 15 SNPs that affect microRNA (miRNA) binding in these lncRNA genes were annotated. Genotyping was performed in 800 HCC cases and 801 healthy controls to examine associations of t

SUBMITTER: Mo H 

PROVIDER: S-EPMC9685961 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature