Association of PPP1R1B polymorphisms with working memory in healthy Han Chinese adults.

ABSTRACT:

Aims

The dopamine- and cAMP-regulated phosphoprotein (DARPP-32), which is encoded by the PPP1R1B gene, plays a converging regulatory role in the central nervous system by mediating the actions of dopamine, serotonin, and glutamate. Previous studies have demonstrated that variations in genes related to the dopamine system influence working memory. The present study thus investigated whether polymorphisms in PPP1R1B gene were associated with working memory.

Materials and methods

A sample of 124 healthy Han Chinese were genotyped for three single nucleotide polymorphisms of PPP1R1B gene, namely rs12601930C/T, rs879606A/G, and rs3764352A/G, using polymerase chain reaction and restriction fragment length polymorphism analysis. Working memory performance was a

SUBMITTER: Ma H 

PROVIDER: S-EPMC9685989 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature