Spatial metabolomics on liver cirrhosis to hepatocellular carcinoma progression.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is one of the deadliest cancers and is mainly developed from chronic liver diseases such as hepatitis-B infection-associated liver cirrhosis (LC). The progression from LC to HCC makes the detection of diagnostic biomarkers to be challenging. Hence, there have been constant efforts to improve on identifying the critical and predictive changes accompanying the disease progression.

Methods

In this study, we looked to using the mass spectrometry mediated spatial metabolomics technique to simultaneous examine hundreds of metabolites in an untargeted fashion. Additionally, metabolic profiles were compared between six subregions within the HCC tissue to collect spatial information.

Results

Through those metabolites, altered metabolic

SUBMITTER: He MJ 

PROVIDER: S-EPMC9686114 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature