Water extract from artichoke ameliorates high-fat diet-induced non-alcoholic fatty liver disease in rats.

ABSTRACT:

Background

The "multiple-hit" hypothesis is currently the most widely accepted theory for non-alcoholic fatty liver disease (NAFLD) pathogenesis. The present study aimed to investigate the effects of the water extract of artichoke (WEA) on NAFLD and its underlying mechanism.

Methods

Rats were fed a high-fat diet (HFD) for 8 weeks to induce NAFLD and then treated with WEA at three doses (0.4, 0.8, and 1.6 g/kg body weight, BW) for 8 weeks. At the end of the intervention, serum biochemical parameters, hepatic antioxidant capacity, hepatic levels of pro-inflammatory cytokines, liver histopathology, hepatic inflammatory gene and lipid metabolism gene expression, and Akt and p-Akt (S473) protein levels were determined.

Results

The body weight, liver weight, liver triglycer

SUBMITTER: Deng A 

PROVIDER: S-EPMC9686119 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature