Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin.

ABSTRACT:

Background

The cohesin complex organizes the genome-forming dynamic chromatin loops that impact on all DNA-mediated processes. There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of the regulatory subunit PDS5, PDS5A and PDS5B. Mice deficient for any of the variant subunits are embryonic lethal, which indicates that they are not functionally redundant. However, their specific behavior at the molecular level is not fully understood.

Results

The genome-wide distribution of cohesin provides important information with functional consequences. Here, we have characterized the distribution of cohesin subunits and regulators in mouse embryo fibroblasts (MEFs) either wild type or deficient for cohesin subunits a

SUBMITTER: Cuadrado A 

PROVIDER: S-EPMC9686121 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature