Stability of motor-nonmotor subtype in early-stage Parkinson's disease.

ABSTRACT:

Background

The different clinical characteristics and prognostic values of the motor-nonmotor subtypes of Parkinson's disease (PD) have been established by previous studies. However, the consistency of motor-nonmotor subtypes in patients with early-stage Parkinson's disease required further investigation. The present study aimed to evaluate the consistency of motor-nonmotor subtypes across five years of follow-up in a longitudinal cohort.

Materials and methods

Patients were classified into different subtypes (mild-motor-predominant, intermediate, diffuse malignant; or tremor-dominant, indeterminate, postural instability and gait difficulty) according to previously verified motor-nonmotor and motor subtyping methods at baseline and at every year of follow-up. The agreement be

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC9686273 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature