White Matter Microstructure in Pediatric Bipolar Disorder and Disruptive Mood Dysregulation Disorder.

ABSTRACT:

Objective

Disruptive mood dysregulation disorder (DMDD) codifies severe, chronic irritability. Youths with bipolar disorder (BD) also present with irritability, but with an episodic course. To date, it is not clear whether aberrant white matter microstructure-a well-replicated finding in BD-can be observed in DMDD and relates to symptoms of irritability.

Method

We acquired diffusion tensor imaging data from 118 participants (BD = 36, DMDD = 44, healthy volunteers (HV = 38). Images of fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD) were processed with tract-based spatial statistics controlling for age and sex. The data were also used to train Gaussian process classifiers to predict diagnostic group.

Results

In BD vs DMDD, FA in the corti

SUBMITTER: Linke JO 

PROVIDER: S-EPMC9686453 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature