ROS-Responsive and pH-Sensitive Aminothiols Dual-Prodrug for Radiation Enteritis.

ABSTRACT: Radiation exposure can immediately trigger a burst of reactive oxygen species (ROS), which can induce severe cell death and long-term tissue damage. Therefore, instantaneous release of sufficient radioprotective drugs is vital to neutralize those accumulated ROS in IR-exposed areas. To achieve this goal, we designed, synthesized, and evaluated a novel oral ROS-responsive radioprotective compound (M1) with high biocompatibility and efficient ROS-scavenging ability to act as a promising oral drug for radiation protection. The compound is stably present in acidic environments and is hydrolyzed in the intestine to form active molecules rich in thiols. M1 can significantly remove cellular ROS and reduce DNA damage induced by γ-ray radiation. An in vivo experiment showed that oral administration

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9686648 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature