Causal associations between blood pressure and the risk of myocardial infarction: A bidirectional Mendelian randomization study

ABSTRACT:

Introduction

Many observational studies imply elevated blood pressure (BP) as a leading risk factor for incident myocardial infarction (MI), but whether this relationship is causal remains unknown. In this study, we used bidirectional Mendelian randomization (MR) to investigate the potential causal association of BP levels with the risk of MI.

Methods

Genetic variants associated with BP and MI traits were retrieved from the International Consortium of Blood Pressure (N = 7,57,601) and UKB (N = 3,61,194), obtaining 1,26,40,541 variants. We used two-sample MR (TSMR) analyses to examine the potential bidirectional causal association of systolic BP (SBP), diastolic BP (DBP) and pulse pressure (PP) with MI.

Results

The forward MR analysis identified a potentially caus

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PROVIDER: S-EPMC9686852 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature