10-mer and 9-mer WALK Peptides with Both Antibacterial and Anti-Inflammatory Activities.

ABSTRACT: Natural antimicrobial peptides (AMPs) are multifunctional host defense peptides (HDPs) that are valuable for various therapeutic applications. In particular, natural and artificial AMPs with dual antibacterial immunomodulatory functions emerged as promising candidates for the development of therapeutic agents to treat infectious inflammation. In an effort to develop useful AMP variants with short lengths and simple amino acid composition, we devised a de novo design strategy to generate a series of model peptide isomer sequences, named WALK peptides, i.e., tryptophan (W)-containing amphipathic-helical (A) leucine (L)/lysine (K) peptides. Here, we generated two groups of WALK peptide isomers: W₂L₄K₄ (WALK244.01~WALK244.10) and W₂L₄K

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC9686928 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature