Sex-Dependent Responses to Maternal Exposure to PM_2.5 in the Offspring.

ABSTRACT: Objective: Particulate matter (PM) with a diameter of 2.5 μm or less (PM_2.5) can cross the blood-placental barrier causing adverse foetal outcomes. However, the impact of maternal exposure to low-levels of PM_2.5 on liver health and the metabolic profile is unclear. This study aimed to investigate hepatic responses to long-term gestational low-dose PM_2.5 exposure, and whether the removal of PM after conception can prevent such effects. Method: Female Balb/c mice (8 weeks) were exposed to PM_2.5 (5 μg/day) for 6 weeks prior to mating, during gestation and lactation to model living in a polluted environment (PM group). In a sub-group, PM_2.5 exposure was stopped post-conception to model mothers moving to areas with clean air (

SUBMITTER: Chen H 

PROVIDER: S-EPMC9686974 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature