Exogenous L-Glutathione Improves Vitrification Outcomes in Murine Preimplantation Embryos.

ABSTRACT: Vitrification is an important tool to store surplus embryos in assisted reproductive technology (ART). However, vitrification increases oxidative damage and results in decreased viability. Studies have reported that L-glutathione (GSH) supplementation improves the preimplantation development of murine embryos. Glutathione constitutes the major non-protein sulphydryl compound in mammalian cells, which confers protection against oxidative damage. However, the effect of GSH supplementation on embryonic vitrification outcomes has yet to be reported. This study aims to determine whether GSH supplementation in culture media improves in vitro culture and vitrification outcomes, as observed through embryo morphology and preimplantation development. Female BALB/c mice aged 6−8 weeks were superovula

SUBMITTER: Abdul Rahman NS 

PROVIDER: S-EPMC9686984 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature